Can't connect to IStore to update my podcasts?
Anyone know why or a fix?

You missing any software updates? I'd run a check for any updates before plugging in and trying to connect.

Wont let me check.
I think it's a firewall or anti-virus software set too high..
I dont think it's a work firewall since I control that on this machine.

Shut off your anti-virus program and shut the firewall off for a few minutes and see if it lets you through, if it does you found the problem if not keep searching and try to do an update.