Between my two jobs, I prolly clean 2 dozen machines a week. Those programs alone still arent enough

I got 5 programs I use religiously to clean out a machine. None of which are Ad Aware/Spybot/Spysweeper. Microsoft Antispyware is the main one. Even in its Beta format, its the best out there.

Then if there is still a problem its time to breakout the spybot or ad aware.. but generally, if there is still a problem at that point, I need to break out the even bigger guns... Couple nasty programs out there that really dig in and strip stuff out but they are not for regular home use.