Hominy Grill is a must do (do it twice or thrice!)
http://hominygrill.com/
Depending on what else you are up for (a very foodie place is Charleston) Halls Chop House, Circa 1886, FIG, Slightly North of Broad, Five Loaves, Chez Nous are all top shelf......I could do 'em all and empty the wallet doing it, if you know what I mean.
Best bet is to check out Zagat or Trip Advisor or Yelp (depending on your preference) and see what appeals to you. Or just walk around and see what you like. Works for me. Most places are pretty darn good or out of business.
Have fun. I am right behind you the first week of November. An annual event I can hardly wait for!