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In general I use 50lb braid for my running line and like to use a 40lb leader. I will tie the braid to a swivel with a Palomar knot and then tie 3-4 ft of leader to the swivel again with a Palomar knot. I will then attach a snap to the end of the leader again with a Palomar knot. I like this set-up and it has worked well for me. I will also carry several pre-tied leaders having the snap and swivel attached so it is easy to change when needed. I have it to the point that I can tie a Palomar knot very quickly and it is a very strong connection that I have a lot of faith in.
Some may think that the 50lb braid and 40lb leader may be overkill but I usually fish around a lot of structure, hang-ups and a need to muscle fish are part of my fishing experience. Plus I do not like to play a fish to exhaustion
If I am jigging around jetties or rocks with a good current I usually move to 65lb running line and a 50lb leader using the same setup.
With regard to fluorocarbon, the majority of my fishing is in the dark. I have used both and have not noticed a significant difference in hook-ups using fluoro or regular clear mono.
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