Vince, I hear ya. I'm burning out ... in Midtown. My last job downtown was a few blocks away from WTC - I left it shortly before 9/11. I used to eat lunch in the basement of that complex, I can't believe it's gone.
You're burned out.
Best advice I hear from career counselors is this:
Pursue a career where your interests overlap with your abilities.
One good place to start is
http://www.assessment.com
Pay a few bucks, take an online assessment. Might be helpful in focusing you.
Personality type also plays a role in what would be a good career matchup. A very helpful book I've read is...
"Do What You Are" by Paul D. Tieger & Barbara Barron-Tieger. (2001, Little, Brown)
This goes a bit into the Meyers-Briggs Type Indicator (MBTI) - fascinating reading.
Lastly, talk to a coach - feedback is enormously valuable.
Hope this helps....
-Ben