List of stuff thats WORKS
Norton AV 2004 +
http://housecall.antivirus.com or panda activescan (
www.pandasoftware.com)
Norton has really started to dissapoint me lately, it dosen't seem to catch as much stuff as say Housecall or Sophos (a corporate solution thats very expensive) do. But its still a nice resident AV program that does a good job protecting e-mail and general system viruses that most people will catch.
Ad-Aware + Spybot 1.3 (catches EVERYTHING... one will pick up stuff the other dosen't)
If you have super entrenched trojans and whatnot, TDS-3 does wonders, it can kill just about any running process and delete it before it can reactive itself.
The latest VX2/f's have been a total nightmare to remove from systems so TDS-3 has almost been a necessity for tearing crap out. It'll also find alot of inactive trojans that Ad-Aware and Spybot don't catch.
If you're not computer literate I'd avoid using TDS-3, you can really do some major damage to a system with it if you're not careful.