The spine or spline as some say is everything in the performance of the rod, when a blank is manufactured, the heavier molecules drop to one side, thus creating a high side or spine, the optimum load of the rod requires the spine to be correct. For instance, if the spine is to the right, the rod will cast to that side. What you can do is remove the reel seat and turn it around, you can do this by removing the foregrip, then heat the reel seat with a heat gun, which will loosen the epoxy, then pull off the reel seat re-epoxy in new position, if this is an inexpensive rod, don't do anything, buy yourself a new rod.
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