If the mouse can move around, it's not really "locked up"...but "non responsive" (I think that's the term for it). That was an important thing to mention :-P
Does your antivirus program have some sort of emergency CD you can boot up from to scan your system? Sounds more like a virus now...
If it's not 10:27, can you bring up your task manager and regedit?
If you get these msgs, a virus did it:
http://www.raymond.cc/blog/archives/...bled-by-virus/