I've never used spybot, so I have no idea.  I have recommended ad-aware to people who've complained MSIE is slow and it's cleaned it up.
ccleaner is here: 
http://www.ccleaner.com/
And FWIW, I haven't had to do a full system reinstall of Windows for over 10yrs.  I'm just OCD on keeping it clean :-)
 ken