This one is a pain in the buttocks and I usually don't fix it remotely. If you are somewhat technically inclined do this:
Get you data backed up onto another disk - vital in case you blow it up
Turn off system restore points, if you clean it and have system restore on it just recreates itself
go into msconfig and turn off the stuff that runs in startup that is not vital
scan the daylights out of it with a new and up to date AV system
Run Dr Web's Cure It
There are other things that may be needed as it changes over time
A clean wipe is sometimes the best bet...
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