I've been using both wire and lead core for many years.
When jigging 4.5-6 oz jigs, wire is essential to get near the bottom in the 30-45 feet I normally fish. Lead core just can't compete.
I like lead core for spoons and especially for tube 'n worm since I feel the running line is more flexible and the action on the lure is better. When jigging, the fisherman imparts the action so I'm less concerned about that with wire.
In years past, I kept a pair of wire rods (with Penn 113Hs) and a pair lead core rods (with Penn 49's) on board at all times. But now that I'm fishing more for tuna and doing a lot of mixed bass/tuna trips I need to have my 80lb standup tuna gear on board, so either the wire or the lead-core set ups must go. So after much consideration, the wire stays...the lead stays home (with apologies to JohnnyD who hates wire)

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