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Symantec 11 S.E.P. hoses servers, especially SBS boxes. I have a client that got it for free and it brings a Quad Core XEON with 4GB ram to its knees (and this is after the upgrades and recommendations from Symantec)...
Is this a single server domain environment, multi server domain environment or workgroup?
Install the Server 2003 Resource Kit / Diagnostic tools, run DCDIAG (pretty sure that is in 2K3), see if you can ping the FQDM of the server from a workstation when the shares are offline.
If not the SEP like TDF said, I'd really suspect it is that DNS/AD is failing internally but really need to know more, especially if SBS
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