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If you go with a prescription, I've had good luck with Transderm Scop. It's a small patch that goes behind your ear. No drowsiness, thirst, or loss of appetite. In rough seas it could get wet and come off, but you put it on the night before so by then it's in your system. I've heard ginger anything (ginger snaps, ginger ale, etc) are good to have along, too.
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